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Human PBMCs from disease-state donors

  • PBMCs from disease-state donors with confirmed diagnosis
  • PBMCs from healthy donors 
  • Broad coverage of general and rare disease areas incl. medical metadata
  • Immediate access to a large inventory of banked samples
  • Custom prospective collection via our own network of partner collection sites
  • IRB-approved sample collection in the EU with informed consent
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High-quality peripheral blood mononuclear cells (PBMCs) for research

BIOMEX provides high‑quality human PBMCs sourced from both healthy and disease‑state donors, processed under rigorously controlled conditions. They are suitable for a wide range of translational and preclinical research applications, including biomarker discovery, assay development, and immunology studies.

Available disease areas

  • Oncology 
    (solid and hematolocial tumors)
  • Autoimmune diseaes
  • Infectious diseases
  • Neurology
  • Gastroenterology/Nephrology
  • Dermatology

Donor and medical data

  • Demographic data (i.e. sex, age, race)
  • Diagnosis (incl. ICD-10 code)
  • Medication
  • Disease/treatment history
  • Disease‑specific clinical scores and staging

For available donor data details see below.

PBMC solutions for your research needs

Samples are available from banked inventory or can be collected prospectively based on defined criteria.

Banked healthy and disease-state PBMCs

  • Immediate availability for time-critical projects
  • Large inventory of in stock disease-state and healthy donors
  • Available cryovial sizes from 5 Mio to 100 Mio cells/vial

Prospective PBMC collection

  • Custom PBMC sourcing based on defined inclusion and exclusion criteria
  • Access to 100+ disease conditions 
  • Available matched plasma/serum
  • Additional testing on demand (e.g. HLA, FACS)

Both approaches ensure high-quality PBMC material aligned with regulatory and ethical requirements.

Our experts will review your request and provide an overview of available PBMC samples from patients or healthy donors, along with information on feasibility and an estimated timeline.

Cell Count(s): Diesease state: 5 Mio or 10 Mio cells/vial. Healthy: 10,20, 50 or 100 Mio cells/vial.

Collection source: Whole blood or apheresis.

Hematology analysis: Quantification of total leukocytes, erythrocytes, platelets, differential white blood cell populations (neutrophils, lymphocytes, monocytes), and calculated PBMC counts is performed using a Sysmex XN‑330.

Cell viability: High post‑thaw viability (>90%) for healthy donor PBMCs using standardized cryopreservation; disease‑state samples may show biological variability.

Anticoagulant: Sodium citrate 3,2%.

Cryopreservation: CryoStor CS10 or FCS. 

Depending on the requested PBMCs and study requirements, the following donor information and sample characterization data can be provided:

Donor demographics: Age, sex, ethnicity, smoking status.

Serology: HIV, HBs-Ag, HCV.

Immunogenetics: 6-digit resolution HLA Class I and Class II characterization, and FCGR3A polymorphism status (on demand).

Clinical background: Diagnosis and disease indication (ICD-10), concomitant medications, treatment and disease status, allergies, relevant comorbidities or additional diseases.

All data are provided in accordance with ethical approvals, informed consent, and applicable data protection regulations.

The publications below illustrate the application of our products in research settings.  

  • Roessner, P.M., Hanna, B.S., Öztürk, S., Schulz, R., Llaó Cid, L., Yazdanparast, H., Scheffold, A., Colomer, D., Stilgenbauer, S., Lichter, P. and Seiffert, M. (2020). TBET-expressing Th1 CD4+ T cells accumulate in chronic lymphocytic leukaemia without affecting disease progression in Eµ-TCL1 mice. Br J Haematol, 189: 133-145. https://doi.org/10.1111/bjh.16316

  • Medina Diaz I., Nocon A., Mehnert D.H., Fredebohm J., Diehl F., Holtrup H. (2016). Performance of Streck cfDNA Blood Collection Tubes for Liquid Biopsy Testing. PLOS ONE 11(11): e0166354. https://doi.org/10.1371/journal.pone.0166354
     
  •  Llaó-Cid, L., Roessner, P.M., Chapaprieta, V. et al. (2021). EOMES is essential for antitumor activity of CD8+ T cells in chronic lymphocytic leukemia. Leukemia 35, 3152–3162. https://doi.org/10.1038/s41375-021-01198-1 

 

Empowering scientists with trusted starting materials

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Worldwide shipping

Based in Heidelberg, Germany, BIOMEX ships biospecimens worldwide using compliant, temperature‑controlled logistics.

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Certified quality

BIOMEX operates an ISO 9001:2015–certified quality management system, audited regularly to ensure compliance and operational excellence.

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Ethically compliant

All biospecimen collections follow GCP, GLP, and GDPR requirements, with full Ethics Committee / IRB approval.

Questions? We’ve got answers

How are disease states defined and verified?

Disease‑state donors are clinically characterized through diagnoses confirmed by our partner physicians using validated diagnostic procedures, supported by medical history and relevant clinical parameters. Available donor metadata may include diagnosis (e.g., ICD‑10 code), treatment history, and disease‑specific clinical scores, depending on indication. 

What performance can I expect post‑thaw (viability and functionality)?

Our cryopreserved PBMCs are processed using standardized workflows to support strong post‑thaw viability and reliable downstream performance; disease‑state material may show biological variability driven by indication and prior treatment.

What compliance and ethics standards apply to these samples?

All biospecimens are collected under Ethics Committee/IRB‑approved protocols with informed consent, and are handled in alignment with GCP, GLP, and GDPR requirements.

Can I access repeat donors or matched PBMC lots for follow‑up studies?

Yes. Where available, PBMCs from healthy donors can be supplied from the same donor across multiple aliquots or collections to support experimental reproducibility and longitudinal study designs. Pooled or matched donor sets may also be available depending on study requirements.

What formats, cell numbers, and customization options are available?

Disease‑state PBMCs are available in cryopreserved formats across a range of cell counts and aliquot sizes. Custom options - including donor criteria, disease indication, collection source (e.g. whole blood or apheresis), and metadata depth - may be supported upon request.

How can I partner with BIOMEX for my project?

Your success is our focus. Learn more about how we work.

How can I purchase from BIOMEX?

Choose the option that works best for you:

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Explore our services, capabilities, and available biospecimens.

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Send us the details of what you need — we’ll respond promptly.

Or contact us directly by email or phone.
р +49 6221 4166-0
esales at biomex.de

How do I contact customer support?

Simply contact our German office:

р +49 6221 4166-0
e sales at biomex.de