High-Quality Leukopaks | Fresh & Cryopreserved

Fresh Leukopaks are collected in BIOMEX’s own plasma centers in Germany using the Spectra Optia™ apheresis system and acid‑citrate‑dextrose solution A (ACD‑A) as anticoagulant. Each leukopak delivers a high‑density mononuclear cell profile, typically enriched with up to 20% monocytes, 50% T cells, 10% B cells, and 10% natural killer cells, clearly outperforming buffy coat–derived material. Full documentation is included, such as donor metadata, HLA typing, complete blood count, and pathogen testing, with additional testing available on request.

Collection method: Leukapheresis using the Spectra Optia™ apheresis system

Hematology analysis: Quantification of total leukocytes, erythrocytes, platelets, differential white blood cell populations (neutrophils, lymphocytes, monocytes) is performed using a Sysmex XN‑330

Anticoagulant: Acid-citrate-dextrose solution A (ACD-A)

Storage (fresh Leukopaks): Refrigerated temperature (2-8°C) directly after collection

Storage (cryo Leukopaks): Same‑day processing with controlled‑rate cryopreservation and storage in liquid nitrogen (vapor phase)

Donor demographics: Age, sex, race/ethnicity, BMI, smoking status

Serology: Anti-HIV 1/2, Anti-HCV, HBs-Ag

Immunogenetics: 6-digit resolution HLA Class I and Class II characterization (on demand)

Clinical background: Disease, medication, allergies (self-reported)

Ethics: All donor collections are conducted under informed consent and Institutional Review Board (IRB)–approved protocols

Depending on the requested donor and study requirements, additional donor information and sample characterization data can be provided on demand.

How are healthy donors defined for leukopak production?

Healthy donors are individuals who self‑report as being in good health based on a standardized donor questionnaire and eligibility assessment conducted prior to each collection. For every leukopak collection, donors undergo serological testing for key infectious diseases, including HIV, hepatitis B (HBV), and hepatitis C (HCV), to support product safety and quality. Only collections meeting these health and testing criteria are released as healthy donor leukopaks.

What viability and functionality can be expected from leukopaks?

Leukopaks are collected by leukapheresis and typically provide high cell viability and functional immune cell populations at release, suitable for downstream research and manufacturing applications. Fresh leukopaks generally show excellent immediate viability and preserved functionality of T cells, B cells, NK cells, and monocytes, while cryopreserved leukopaks are processed using controlled‑rate freezing to maintain robust post‑thaw viability and functional recovery. Actual viability and functional performance may vary depending on donor characteristics, processing, storage, and the specific assay or application used.

What compliance and ethics standards apply to these samples?

All biospecimens are collected under Ethics Committee/IRB‑approved protocols with informed consent, and are handled in alignment with GCP, GLP, and GDPR requirements.

How does donor recall work for leukopak collections?

We support donor recall by operating two plasma donation centers (Heidelberg and Munich, Germany) and performing leukopak collections routinely, enabling reliable access to repeat donations. With donor consent and eligibility confirmed for each visit, pre‑screened donors can be re‑contacted and scheduled for follow‑up collections to support longitudinal studies or consistent manufacturing inputs. Recall timing and availability depend on donor eligibility, health status at the time of collection, and scheduling capacity.

What formats, cell numbers, and customization options are available?

Leukopaks are available in quarter, half, full, and double formats, corresponding to approximately ≥2.5, ≥5, ≥10, and ≥20 billion total cells, respectively. Customers can select from a range of additional QC and characterization options, including extended immunophenotyping by flow cytometry, HLA typing, and other custom assays. Custom donor inclusion or exclusion criteria can be applied based on clinical, demographic, or immunological requirements. In addition, logistics and delivery solutions can be tailored to match your required timelines, whether for time‑critical fresh deliveries or flexible cryopreserved supply.

How can I partner with BIOMEX for my project?

Your success is our focus. Learn more about how we work.

How can I purchase from BIOMEX?

Choose the option that works best for you:

Visit our website
Explore our services, capabilities, and available biospecimens.

Browse in the Sampleshop
Register for full access and request directly online.

Submit a request form
Send us the details of what you need — we’ll respond promptly.

Or contact us directly by email or phone.
р +49 6221 4166-0
e sales at biomex.de

How do I contact customer support?

Simply contact our German office:

р +49 6221 4166-0
e sales at biomex.de

High-quality Leukopaks for research and manufacturing

Fresh Leukopaks with high mononuclear cell density

Flexible Leukopak supply

Custom QC & donor profiling capabilities

Leukopaks for your research needs

Fresh Leukopaks

Cryopreserved Leukopaks

Empowering scientists with trusted starting materials

Worldwide shipping

Certified quality

Ethically compliant

Questions? We’ve got answers